Among the highlights, Plymouth Argyle, currently bottom of the Championship after sacking manager Wayne Rooney, will host eight-time winners Liverpool in what promises to be a significant David-versus-Goliath clash.
Plymouth secured their spot in the fourth round with a shocking 1-0 victory over Premier League side Brentford, making their matchup against Arne Slot's Reds one to watch. Liverpool will aim to avoid a similar upset as they travel to Home Park.
League One leaders Birmingham City will welcome in-form Newcastle United, while fellow third-tier side Exeter City will play surprising Premier League contenders Nottingham Forest at home. Holders Manchester United, fresh off their dramatic penalty shootout win over Arsenal, will take on 2021 winners Leicester City at Old Trafford, with Leicester's boss Ruud Van Nistelrooy coming back to Old Trafford after his interim charge as Manchester United boss late last year.
Three all-Premier League clashes are set to capture attention:
Manchester City, who thrashed Salford City 8-0 in the third round, will travel to face either Leyton Orient or Derby County, depending on the outcome of their postponed third-round fixture.
National League side Dagenham & Redbridge, the lowest-ranked team still in the competition, could face Leeds United if they overcome Millwall in their third-round tie. Meanwhile, League Two's Doncaster Rovers will host Crystal Palace, providing another opportunity for a potential upset.
Other matches include Blackburn Rovers taking on Wolverhampton Wanderers and Southampton playing Burnley. Stoke City will host Cardiff City, while Coventry City meets Ipswich Town in an all-Championship tie.
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The final will be played at Wembley Stadium, London, on May 17.
